TRAF2 Antikörper (AA 261-360) (Biotin)

Produktnummer ABIN7091744

Dieses Anti-TRAF2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von TRAF2 in WB. Geeignet für Human, Maus und Ratte.

Kurzübersicht für TRAF2 Antikörper (AA 261-360) (Biotin) (ABIN7091744)

Target: TRAF2 (TNF Receptor-Associated Factor 2 (TRAF2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TRAF2 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB)

Produktdetails anti-TRAF2 Antikörper (Biotin)

Bindungsspezifität: AA 261-360

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TRAF2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu TRAF2

Target: TRAF2 (TNF Receptor-Associated Factor 2 (TRAF2))

Andere Bezeichnung: TRAF2

Hintergrund:

Synonyms: E3 ubiquitin-protein ligase TRAF2, TNF-R2, TNF R2, MGC:45012, OTTHUMP00000022625, OTTHUMP00000064745, TNF receptor associated factor 2, TNF receptor-associated factor 2, TNF receptor-associated protein, TRAF 2, TRAF2_HUMAN, TRAP 3, TRAP, TRAP3, Tumor necrosis factor type 2 receptor associated protein 3, Tumor necrosis factor type 2 receptor-associated protein 3.

Background: Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation, this does not depend on the TRAF2 RING-type zinc finger domain. Isoform 2 does not seem to mediate activation of NF-kappa-B but inhibits isoform 1 activity. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.

Gen-ID: 7186

UniProt: Q12933

Pathways: NF-kappaB Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Unfolded Protein Response, S100 Proteine