EPAS1 Antikörper (AA 471-570) (HRP)

Produktnummer ABIN7091059

Der Kaninchen Polyklonal Anti-EPAS1-Antikörper wurde für ELISA und IHC (p) validiert. Er ist geeignet, EPAS1 in Proben von Ratte zu detektieren.

Kurzübersicht für EPAS1 Antikörper (AA 471-570) (HRP) (ABIN7091059)

Target: EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EPAS1 Antikörper ist konjugiert mit HRP

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-EPAS1 Antikörper (HRP)

Bindungsspezifität: AA 471-570

Kreuzreaktivität: Ratte

Homologie: Human,Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HIF 2 alpha

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P 1:200-400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Details zu EPAS1

Target: EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))

Andere Bezeichnung: HIF 2 alpha

Hintergrund:

Synonyms: Basic helix loop helix PAS protein MOP2, Basic-helix-loop-helix-PAS protein MOP2, bHLHe73, Class E basic helix-loop-helix protein 73, ECYT4, Endothelial PAS domain containing protein 1, Endothelial pas domain protein 1, Endothelial PAS domain-containing protein 1, EPAS 1, EPAS-1, EPAS1, EPAS1_HUMAN, HIF 1 alpha like factor, HIF 2 alpha, HIF-1-alpha-like factor, HIF-2-alpha, HIF2-alpha, HIF2A, HLF, Hypoxia inducible factor 2 alpha, Hypoxia inducible factor 2 alpha subunit, Hypoxia-inducible factor 2-alpha, Member of PAS protein 2, Member of pas superfamily 2, MOP 2, MOP2, PAS domain-containing protein 2, PASD2.

Background: Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD.

Gen-ID: 2034

UniProt: Q99814

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2, Warburg Effekt