CDKN2B Antikörper (HRP)

Produktnummer ABIN706175

Der Kaninchen Polyklonal anti-CDKN2B Antikörper wird verwendet zum Nachweis von CDKN2B in Proben von Human. Er wurde validiert für WB und IHC (p).

Kurzübersicht für CDKN2B Antikörper (HRP) (ABIN706175)

Target: CDKN2B (Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4) (CDKN2B))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDKN2B Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-CDKN2B Antikörper (HRP)

Verwendungszweck: CDKN2B/p15 INK4b Polyclonal Antibody, HRP Conjugated

Kreuzreaktivität: Huhn, Rind (Kuh), Hund, Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CDKN2B

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB(1:300-5000), IHC-P(1:200-400)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu CDKN2B

Target: CDKN2B (Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4) (CDKN2B))

Andere Bezeichnung: CDKN2B

Hintergrund:

Synonyms: CDK inhibitory protein, CDK4B Inhibitor, CDKN2B, Cyclin dependent kinase 4 inhibitor B, Cyclin Dependent Kinase Inhibitor 2B, Cyclin dependent kinase inhibitor 2B p15 inhibits CDK4, Cyclin-dependent kinases 4 and 6 binding protein, INK4B, MTS 2, MTS2, Multiple Tumor Supressor 2, p14 CDK inhibitor, p14 INK4b, P15, p15 CDK inhibitor, p15 inhibits CDK4, p15 INK4b, P15INK4B, p15INK4B, TP 15, TP15.

Background: p15 INK4b / MTS 2 (Mitotic Inhibitor / Suppressor Protein) is a specific inhibitor of cdk 4 / cdk 6 and is periodically expressed during the cell cycle. Reportedly, p15 INK4b expression is induced approximately 30 fold in human keratinocytes by treatment with TGF beta, suggesting that p15 INK4b may act as an effector of TGF beta mediated cell cycle arrest. p15 INK4b is mapped to chromosome 9p21, a region of frequent loss in a wide variety of cancers.

Molekulargewicht: 15kDa

Gen-ID: 1030

UniProt: P42772

Pathways: Zellzyklus, Mitotic G1-G1/S Phases