BRCA2 Antikörper

Produktnummer ABIN7090792

Produktdetails anti-BRCA2 Antikörper

Target: BRCA2 (Breast Cancer 2, Early Onset (BRCA2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser BRCA2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: Human

Immunogen: Recombinant human BRCA2_HUMAN.

Klon: F2H5

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu BRCA2

Target: BRCA2 (Breast Cancer 2, Early Onset (BRCA2))

Andere Bezeichnung: BRCA2 (BRCA2 Produkte)

Synonyme: BRCC2 antikoerper, BROVCA2 antikoerper, FACD antikoerper, FAD antikoerper, FAD1 antikoerper, FANCB antikoerper, FANCD antikoerper, FANCD1 antikoerper, GLM3 antikoerper, PNCA2 antikoerper, 30169 antikoerper, BcDNA:SD25109 antikoerper, CG13583 antikoerper, CG13584 antikoerper, CG30169 antikoerper, Dmel\\CG30169 antikoerper, brca2 antikoerper, dmbrca2 antikoerper, fancd1 antikoerper, BRCA2 antikoerper, brcc2 antikoerper, brovca2 antikoerper, facd antikoerper, fad antikoerper, fad1 antikoerper, fancb antikoerper, AI256696 antikoerper, AW045498 antikoerper, Fancd1 antikoerper, RAB163 antikoerper, BRCA2, DNA repair associated antikoerper, Breast cancer 2, early onset homolog antikoerper, breast cancer 2, early onset antikoerper, BRCA2 antikoerper, Brca2 antikoerper, brca2 antikoerper, LOC584780 antikoerper

Hintergrund:

Synonyms: BRCA 2, BRCA1/BRCA2 containing complex subunit 2, BRCC 2, BRCC2, Breast and ovarian cancer susceptibility gene early onset, Breast cancer 2 early onset, Breast Cancer 2 tumor suppressor, Breast cancer susceptibility protein BRCA2, Breast cancer type 2 susceptibility protein, FACD, FAD 1, FAD, FAD1, FANCB, FANCD 1, FANCD, FANCD1, Fanconi anemia complementation group D1, Fanconi anemia group D1 protein, OTTHUMP00000018803, OTTHUMP00000042401, BRCA2_HUMAN.

Background: Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. In concert with NPM1, regulates centrosome duplication.

Gen-ID: 675

UniProt: P51587

Pathways: DNA Reparatur, M Phase, Maintenance of Protein Location