BRCA2 Antikörper

Produktnummer ABIN7090792

Der Maus-Monoklonal Anti-BRCA2-Antikörper wurde für WB validiert. Er ist geeignet zum Nachweis von BRCA2 in Proben aus Human. }

Kurzübersicht für BRCA2 Antikörper (ABIN7090792)

Target: BRCA2 (Breast Cancer 2, Early Onset (BRCA2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser BRCA2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: F2H5

Produktdetails anti-BRCA2 Antikörper

Homologie: Human

Immunogen: Recombinant human BRCA2_HUMAN.

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu BRCA2

Target: BRCA2 (Breast Cancer 2, Early Onset (BRCA2))

Andere Bezeichnung: BRCA2

Hintergrund:

Synonyms: BRCA 2, BRCA1/BRCA2 containing complex subunit 2, BRCC 2, BRCC2, Breast and ovarian cancer susceptibility gene early onset, Breast cancer 2 early onset, Breast Cancer 2 tumor suppressor, Breast cancer susceptibility protein BRCA2, Breast cancer type 2 susceptibility protein, FACD, FAD 1, FAD, FAD1, FANCB, FANCD 1, FANCD, FANCD1, Fanconi anemia complementation group D1, Fanconi anemia group D1 protein, OTTHUMP00000018803, OTTHUMP00000042401, BRCA2_HUMAN.

Background: Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. In concert with NPM1, regulates centrosome duplication.

Gen-ID: 675

UniProt: P51587

Pathways: DNA Reparatur, M Phase, Maintenance of Protein Location