ZAP70 Antikörper (AA 247-382) (PE)

Produktnummer ABIN7077616

Dieses Maus Monoklonal-Antikörper erkennt spezifisch ZAP70 in FACS. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für ZAP70 Antikörper (AA 247-382) (PE) (ABIN7077616)

Target: ZAP70 (zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ZAP70 Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Güteklasse: GMP Grade

Klon: C-D12

Produktdetails anti-ZAP70 Antikörper (PE)

Bindungsspezifität: AA 247-382

Verwendungszweck: Zap70 PE Antibody

Produktmerkmale: The clone C-D12, a mouse monoclonal antibody selectively binds with the 70kd tyrosine phosphoprotein known as ZAP-70 which is usually associated with the ζ-chain CD3-receptor-associated protein tyrosine kinase (PTK). It is a member of the Syk family that is localized exclusively to the cytosol of T cells and natural killer (NK) cells and  is required for their cellular activation. It is generally considered the T-lymphocyte counterpart of Syk, a B-cell receptor (BCR)-associated kinase that belongs to the same PTK family and plays a similar role in the antigen receptor signaling in the B-lineage cells. It facilitates the upregulation of Fas ligand in activation-induced T cell apoptosis. ZAP-70 expression plays an important role in the clinical diagnosis of various types of hematologic malignancies.

Aufreinigung: Purified

Reinheit: >95 %

Immunogen: Recombinant fragment of human ZAP70 protein (around aa 247-382)

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS pH 7.2, 0.2 % (w/v) BSA, 0.09 % (w/v) sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: 2-8°C, Conjugated antibodies should never be frozen.

Details zu ZAP70

Target: ZAP70 (zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70))

Andere Bezeichnung: Zap70

Gen-ID: 7535

UniProt: P43403

Pathways: T-Zell Rezeptor Signalweg, Ubiquitin Proteasome Pathway