NLRP1 Antikörper

Produktnummer ABIN7074850

Der Kaninchen Polyklonal anti-NLRP1 Antikörper (ABIN7074850) detektiert spezifisch NLRP1 in IHC und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Maus und Ratte.

Kurzübersicht für NLRP1 Antikörper (ABIN7074850)

Target: NLRP1 (NLR Family, Pyrin Domain Containing 1 (NLRP1))

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NLRP1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-NLRP1 Antikörper

Kreuzreaktivität: Ratte

Aufreinigung: Affinity purification

Immunogen: Recombinant protein corresponding to Mouse NLRP1

Anwendungsinformationen

Applikationshinweise: IHC/IF (M,R) 1:500-1:2000/1:250-1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu NLRP1

Target: NLRP1 (NLR Family, Pyrin Domain Containing 1 (NLRP1))

Andere Bezeichnung: NLRP1

Hintergrund: NACHT, LRR and PYD domains-containing protein 1 is a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. The NLRP1 protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined.

Gen-ID: 195046

NCBI Accession: NP_001004142

UniProt: Q2LKU9

Pathways: Positive Regulation of Endopeptidase Activity, Inflammasome