Rekombinanter IL-6 Receptor Antikörper

Produktnummer ABIN7072548

Produktdetails anti-IL-6 Receptor Antikörper

Target: IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))

Antikörpertyp: Recombinant Antibody

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Chimeric

Konjugat: Dieser IL-6 Receptor Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Blocking Peptide (BP)

Verwendungszweck: Anti-IL-6R [D7715A7], Rabbit IgG, kappa

Spezifität: This antibody is specific for murine IL-6R.

Produktmerkmale:

Original Species of Ab: Rat

Original Format of Ab: IgG2b

Aufreinigung: Protein A affinity purified

Immunogen: This antibody was raised by immunising Lewis rats with OKT4 cells.

Klon: D7715A7

Isotyp: IgG kappa

Anwendungsinformationen

Applikationshinweise: This antibody binds to IL-6R-positive cells, and blocks IL-6 binding (Vink et al, 1990, Coulie et al, 1990). This antibody is able to inhibit the growth of IL6-dependent plasmacytoma T1033C2 in vitro (Coulie et al, 1990). Administration of this antibody to mice prior to challenge with T1033C2 resulted in a protection rate of 60 % and prolonged survival in tumour-bearing mice (Vink et al, 1990). This antibody has been used in flow cytometry to assess IL-6Ra expression (Hoge et al, 2013). When added to dendritic cells subject to CD40 activation in vitro, this antibody neutralises IL-6 and ablates the effect of CD40 activation (Grohmann et al, 2001).

Kommentare:

This chimeric rabbit antibody was made using the variable domain sequences of the original Rat IgG2b format, for improved compatibility with existing reagents, assays and techniques.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Details zu IL-6 Receptor

Target: IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))

Andere Bezeichnung: IL-6R (IL6R Produkte)

Hintergrund: CD126, 15A7, IL-6Ra, IL6R, Interleukin-6 receptor subunit alpha, Il6ra, IL-6 receptor subunit alpha, IL-6R subunit alpha, IL-6R-alpha, IL-6RA, IL-6R 1

UniProt: P22272

Pathways: JAK-STAT Signalweg, Autophagie, Growth Factor Binding, Cancer Immune Checkpoints