TET2 Antikörper (C-Term)

Produktnummer ABIN6991984

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch TET2 in WB und ELISA. Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für TET2 Antikörper (C-Term) (ABIN6991984)

Target: TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TET2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-TET2 Antikörper

Bindungsspezifität: AA 1550-1600, C-Term

Spezifität: TET2 antibody is human and mouse reactive. At least two isoforms of TET2 are known to exist, this antibody will detect the larger isoforms. This antibody is predicted to not cross-react with TET1 and TET3.

Aufreinigung: TET2 antibody is affinity chromatography purified via peptide column.

Immunogen: TET2 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human TET2. The immunogen is located within amino acids 1550 - 1600 of TET2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: TET2 antibody can be used for detection of TET2 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: TET2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: TET2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu TET2

Target: TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))

Andere Bezeichnung: TET2

Hintergrund: TET2, a member of the ten-eleven-translocation (TET) family of genes, is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. It is a candidate tumor suppressor gene reported to be mutated in approximately 14 % of patients with JAK2V617F-positive myeloproliferative neoplasms (1), and can be mutated in other hematopoietic disorders such as myelodysplastic syndromes, acute myeloid leukemia, and chronic myelomonocytic leukemia (2). Analysis of the TET2 and JAK2 mutations in these neoplasms suggests that mutations in TET2 do not represent a predisposition for acquiring mutations in JAK2.

Molekulargewicht: Predicted: 220 kDa

Observed: 220 kDa

Gen-ID: 54790

NCBI Accession: NP_001120680

UniProt: Q6N021

Pathways: Warburg Effekt