KDM1B Antikörper (N-Term)

Produktnummer ABIN6991923

Produktdetails anti-KDM1B Antikörper

Target: KDM1B (Lysine (K)-Specific Demethylase 1B (KDM1B))

Bindungsspezifität: AA 80-130, N-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KDM1B Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Spezifität: KDM1B antibody is human, mouse and rat reactive. At least two isoforms of KDM1B are known to exist, this KDM1B antibody will detect both isoforms.

Aufreinigung: KDM1B antibody is affinity chromatography purified via peptide column.

Immunogen: KDM1B antibody was raised against a 17 amino acid peptide near the amino terminus of human KDM1B. The immunogen is located within amino acids 80 - 130 of KDM1B.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: KDM1B antibody can be used for detection of KDM1B by Western blot at 0.5 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: KDM1B antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: KDM1B antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu KDM1B

Target: KDM1B (Lysine (K)-Specific Demethylase 1B (KDM1B))

Andere Bezeichnung: KDM1B (KDM1B Produkte)

Hintergrund: Flavin-dependent histone demethylases regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function (reviewed in 1). KDM1B is a recently identified histone H3K4 demethylase that is required to establish maternal genomic imprints, targeted disruption of the KDM1B gene in mice led to lethality in their embryos, suggesting demethylation of H3K4 is critical for establishing the DNA methylation imprints (2). KDM1B has also been shown to play a role in the transcription elongation in several genes (3).

Molekulargewicht: Predicted: 90 kDa

Observed: 90 kDa

Gen-ID: 221656

NCBI Accession: NP_694587

UniProt: Q8NB78

Pathways: Warburg Effekt