TET2 Antikörper (N-Term)

Produktnummer ABIN6991708

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch TET2 in WB, ELISA, IHC (p) und IF. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für TET2 Antikörper (N-Term) (ABIN6991708)

Target: TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TET2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Produktdetails anti-TET2 Antikörper

Bindungsspezifität: AA 20-70, N-Term

Spezifität: At least two isoforms of TET2 are known to exist, this antibody will detect both isoforms.

Aufreinigung: TET2 Antibody is affinity chromatography purified via peptide column.

Immunogen: TET2 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human TET2. The immunogen is located within amino acids 20 - 70 of TET2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: TET2 antibody can be used for detection of TET2 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: TET2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: TET2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu TET2

Target: TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))

Andere Bezeichnung: TET2

Hintergrund: TET2 Antibody: TET2, a member of the ten-eleven-translocation (TET) family of genes, is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. It is a candidate tumor suppressor gene reported to be mutated in approximately 14 % of patients with JAK2V617F-positive myeloproliferative neoplasms, and can be mutated in other hematopoietic disorders such as myelodysplastic syndromes, acute myeloid leukemia, and chronic myelomonocytic leukemia. Analysis of the TET2 and JAK2 mutations in these neoplasms suggests that mutations in TET2 do not represent a predisposition for acquiring mutations in JAK2.

Gen-ID: 54790

NCBI Accession: NP_001120680

UniProt: Q6N021

Pathways: Warburg Effekt