ORAI1 Antikörper (N-Term)

Produktnummer ABIN6990716

Der Kaninchen Polyklonal Anti-ORAI1-Antikörper wurde für WB, ELISA, IF und IHC (p) validiert. Er ist geeignet, ORAI1 in Proben von Human und Maus zu detektieren.

Kurzübersicht für ORAI1 Antikörper (N-Term) (ABIN6990716)

Target: ORAI1 (ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ORAI1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-ORAI1 Antikörper

Bindungsspezifität: N-Term

Spezifität: This antibody is predicted to have no cross-reactivity to ORAI2 or ORAI3.

Aufreinigung: ORAI1 Antibody is affinity chromatography purified via peptide column.

Immunogen: ORAI1 antibody was raised against an 18 amino acid synthetic peptide from near the amino terminus of human ORAI1. The immunogen is located within the first 50 amino acids of ORAI1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ORAI1 antibody can be used for detection of ORAI1 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: ORAI1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: ORAI1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu ORAI1

Target: ORAI1 (ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1))

Andere Bezeichnung: ORAI1

Hintergrund: ORAI1 Antibody: Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one form of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor.

Molekulargewicht: Predicted: 33 kDa

Observed: 50 kDa

Gen-ID: 84876

UniProt: Q96D31

Pathways: T-Zell Rezeptor Signalweg, BCR Signaling