NOD2 Antikörper (N-Term)

Produktnummer ABIN6990388

Produktdetails anti-NOD2 Antikörper

Target: NOD2 (Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NOD2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: At least four isoforms of NOD2 are known to exist, this antibody will only detect the longest isoform. NOD2 has no cross-reaction with NOD1.

Aufreinigung: NOD2 Antibody is immunoaffinity chromatography purified IgG.

Immunogen: NOD2 antibody was raised against a synthetic peptide corresponding to 16 amino acids at the amino terminus of human NOD2. The immunogen is located within the first 50 amino acids of NOD2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: NOD2 antibody can be used for detection of NOD2 by Western blot at 1 to 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 10 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: NOD2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: NOD2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu NOD2

Target: NOD2 (Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2))

Andere Bezeichnung: NOD2 (NOD2 Produkte)

Synonyme: ACUG antikoerper, BLAU antikoerper, CARD15 antikoerper, CD antikoerper, CLR16.3 antikoerper, IBD1 antikoerper, NLRC2 antikoerper, NOD2B antikoerper, PSORAS1 antikoerper, Card15 antikoerper, F830032C23Rik antikoerper, Nlrc2 antikoerper, caspase recruitment domain 15 protein antikoerper, nucleotide binding oligomerization domain containing 2 antikoerper, nucleotide-binding oligomerization domain containing 2 antikoerper, TTHERM_01951320 antikoerper, NOD2 antikoerper, Nod2 antikoerper

Hintergrund: NOD2 Antibody: Apaf-1 and NOD1 are members of a new family, which are involved in the regulation of apoptosis and immune response. Each of them contains a caspase recruitment domain (CARD) and a nucleotide-binding oligomerization domain (NOD). A third member in this family was recently identified and designated NOD2. NOD2 interacts with RICK via a homophilic CARD-CARD interaction. NOD2 activates NF-κ,B, which is regulated by its carboxy-terminal leucine-rich repeat domain that acts as an intracellular receptor for components of bacteria. The variants of NOD2, either a frameshift or a missense, were associated with Crohn's disease that is a main type of chronic inflammatory bowel disease.

Molekulargewicht: Predicted: 114 kDa

Observed: 100 kDa

Gen-ID: 64127

UniProt: Q9HC29

Pathways: Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome