BCL10 Antikörper (N-Term)

Produktnummer ABIN6990308

Produktdetails anti-BCL10 Antikörper

Target: BCL10 (B-Cell CLL/lymphoma 10 (BCL10))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BCL10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Aufreinigung: Bcl-10 Antibody is affinity chromatography purified via peptide column.

Immunogen: Bcl10 antibody was raised against a peptide corresponding to amino acids near the amino terminus of human Bcl10. The immunogen is located within the first 50 amino acids of Bcl-10.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Bcl-10 antibody can be used for detection of BCL10 by Western blot at 0.5 μ,g/mL. dilution. An approximately 31 kDa band can be detected. Antibody can also be used for immunocytochemistry starting at 1 μ,g/mL. For immunofluorescence start at 10 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Bcl-10 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: Bcl-10 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu BCL10

Target: BCL10 (B-Cell CLL/lymphoma 10 (BCL10))

Andere Bezeichnung: Bcl-10 (BCL10 Produkte)

Synonyme: CARMEN antikoerper, CIPER antikoerper, CLAP antikoerper, c-E10 antikoerper, mE10 antikoerper, BCL10 antikoerper, AI132454 antikoerper, BCL-10 antikoerper, C81403 antikoerper, ME10 antikoerper, cE10 antikoerper, bcl10 antikoerper, B-cell CLL/lymphoma 10 antikoerper, B-cell lymphoma/leukemia 10-like antikoerper, B cell leukemia/lymphoma 10 antikoerper, B-cell lymphoma/leukemia 10 antikoerper, BCL10 antikoerper, Bcl10 antikoerper, bcl10 antikoerper, LOC100223183 antikoerper

Hintergrund: Bcl-10 Antibody: Apoptosis is related to many diseases including cancer. Cell death signals are transduced by death domain (DD) and caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include ARC, RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD containing protein was recently identified by several groups and designated Bcl10, CIPER, mE10, CARMEN, CLAP. Bcl10 is a cellular homolog of the equine herpesvirus-2 E-10 gene. Overexpression of Bcl10 induces JNK, p38, and NF-κ,B activation. Bcl10 interacts with caspase-9 and enhances pro-caspase-9 processing and induces apoptosis through caspase-9 activation. Bcl10 exhibits a variety of mutations in MALT lymphomas and in B and T cell lineage lymphomas indicating that it may be commonly involved in the pathogenesis of human malignancy. Bcl10 is expressed in many human and murine tissues and cell lines.

Molekulargewicht: 31 kDa

Gen-ID: 8915

UniProt: O95999

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteine