XBP1 Antikörper (N-Term)

Produktnummer ABIN6990120

Dieses Anti-XBP1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von XBP1 in WB, ELISA, IF, ICC und IHC (p). Geeignet für Human, Maus und Ratte.

Kurzübersicht für XBP1 Antikörper (N-Term) (ABIN6990120)

Target: XBP1 (X-Box Binding Protein 1 (XBP1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser XBP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-XBP1 Antikörper

Bindungsspezifität: AA 40-90, N-Term

Aufreinigung: XBP-1 Antibody is affinity chromatography purified via peptide column.

Immunogen: Anti-XBP-1 antibody was raised against a peptide corresponding to 17 amino acids near the amino terminus of human XBP-1. The immunogen is located within amino acids 40 - 90 of XBP-1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 0.25-2 μ,g/mL, IF: 20 μ,g/mL, ICC: 10 μ,g/mL, IHC: 2-5 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunofluorescence in human and rat samples, Immunocytochemistry in human samples, Immunohistochemistry in human, mouse, and rat samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: XBP-1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: XBP-1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu XBP1

Target: XBP1 (X-Box Binding Protein 1 (XBP1))

Andere Bezeichnung: XBP-1

Hintergrund: XBP-1 Antibody: X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of malfolded proteins in the endoplasmic reticulum (ER). Upon sensing unfolded proteins, an ER transmembrane endonuclease and kinase termed IRE1p is activated and excises an intron from XBP-1 mRNA. The spliced XBP-1 mRNA results in a 371 amino acid protein (XBP-1s) which is then translocated to the nucleus where it binds to the regulatory elements of downstream genes. Together with other UPR transcription factors such as ATF6, XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones glucose regulated protein (GRP) 78 and GRP94.

Molekulargewicht: Predicted: 28/40kD

Observed: 28/40 kD kDa

Gen-ID: 7494

UniProt: P17861

Pathways: ER-Nucleus Signaling, Unfolded Protein Response