EPAS1 Antikörper (AA 1-130) (PE)

Produktnummer ABIN6988372

Produktdetails anti-EPAS1 Antikörper (PE)

Target: EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))

Bindungsspezifität: AA 1-130

Reaktivität: Human, Ratte, Maus, Affe, Schaf

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EPAS1 Antikörper ist konjugiert mit PE

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Kreuzreaktivität: Human, Affe, Maus, Ratte, Schaf

Homologie: Cow,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse HIF2 Alpha

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM 1:20-100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu EPAS1

Target: EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))

Andere Bezeichnung: HIF2 alpha (EPAS1 Produkte)

Hintergrund:

Synonyms: HLF, HRF, MOP2, HIF2A, bHLHe73, HIF-2alpha, Endothelial PAS domain-containing protein 1, EPAS-1, HIF-1-alpha-like factor, mHLF, HIF-related factor, Hypoxia-inducible factor 2-alpha, HIF-2-alpha, HIF2-alpha, Epas1

Background: Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBPB and probably EP3. Interaction with redox regulatory protein APEX seems to activate CTAD (By similarity).

Gen-ID: 13819

UniProt: P97481

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2, Warburg Effekt