JAK1 Antikörper (HRP)

Produktnummer ABIN6988045

Dieses Maus Monoklonal-Antikörper erkennt spezifisch JAK1 in IHC (p) und IHC (fro). Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für JAK1 Antikörper (HRP) (ABIN6988045)

Target: JAK1 (Janus Kinase 1 (JAK1))

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser JAK1 Antikörper ist konjugiert mit HRP

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: 9G7

Produktdetails anti-JAK1 Antikörper (HRP)

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein G.

Immunogen: KLH conjugated synthetic peptide derived from human JAK1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu JAK1

Target: JAK1 (Janus Kinase 1 (JAK1))

Andere Bezeichnung: JAK1

Hintergrund:

Synonyms: JAK 1, JAK 1A, JAK 1B, JAK1, JAK1A, JAK1B, Janus kinase 1 (a protein tyrosine kinase), Janus kinase 1, JTK3, Tyrosine protein kinase JAK 1, Tyrosine protein kinase JAK1, JAK1_HUMAN.

Background: Janus kinase 1 (JAK1) is a member of a new class of non-receptor protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. It is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon recpeptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.

Gen-ID: 3716

UniProt: P23458

Pathways: JAK-STAT Signalweg, RTK Signalweg, Interferon-gamma Pathway, Hepatitis C, Toll-Like Receptors Cascades, Unfolded Protein Response