MCL-1 Antikörper (AA 101-200) (HRP)

Produktnummer ABIN6987887

Der Kaninchen Polyklonal Anti-MCL-1-Antikörper wurde für WB, IHC (p) und IHC (fro) validiert. Er ist geeignet, MCL-1 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für MCL-1 Antikörper (AA 101-200) (HRP) (ABIN6987887)

Target: MCL-1 (MCL1) (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MCL-1 Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-MCL-1 Antikörper (HRP)

Bindungsspezifität: AA 101-200

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MCL1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu MCL-1

Target: MCL-1 (MCL1) (Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1))

Andere Bezeichnung: MCL1

Hintergrund:

Synonyms: myeloid cell leukemia 1, myeloid cell leukemia sequence 1, MCL-1, MCL1L, MCL 1, mcl1/EAT, MGC104264, MGC1839, TM, MCL1S, EAT) Bcl 2 related protein EAT/mcl1, BCL2 related, BCL2L3, EAT, Induced myeloid leukemia cell differentiation protein Mcl 1, myeloid cell leukemia sequence 1, Myeloid cell leukemia sequence 1 BCL2 related, Myeloid cell leukemia sequence 1 isoform 1, OTTHUMP00000032794, OTTHUMP00000032795, TM, bcl2-L-3, BCL2L3, EAT, Mcl-1, MCL1-ES, mcl1/EAT.

Background: Mcl1 is an anti-apoptotic member of Bcl2 family originally isolated from the ML1 human myeloid leukemia cell line during phorbol ester-induced differentiation along the monocyte/macrophage pathway. Mcl1 localizes to the mitochondria, interacts with and antagonizes pro-apoptotic Bcl2 family members, and inhibits apoptosis by a number of cytotoxic stimuli. It is involved in programing of differentiation and concomitant maintenance of viability but not of proliferation. Isoform 1 inhibits apoptosis while isoform 2 promotes it. Expression increases early during phorbol-ester induced differentiation along the monocyte/macrophage pathway in myeloid leukemia cell lines ML1.

Gen-ID: 4170

UniProt: Q07820

Pathways: MAPK Signalweg