MAP2 Antikörper (pThr1613, pThr1619) (Cy5)

Produktnummer ABIN6984242

Produktdetails anti-MAP2 Antikörper (Cy5)

Target: MAP2 (Microtubule-Associated Protein 2 (MAP2))

Bindungsspezifität: pThr1613, pThr1619

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAP2 Antikörper ist konjugiert mit Cy5

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Cow,Pig,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthesised phosphopeptide derived from human MAP2 around the phosphorylation site of Thr1613 and Thr1619

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu MAP2

Target: MAP2 (Microtubule-Associated Protein 2 (MAP2))

Andere Bezeichnung: MAP2 (MAP2 Produkte)

Synonyme: MAP2A antikoerper, MAP2B antikoerper, MAP2C antikoerper, MAP2R antikoerper, Mtap2 antikoerper, MAP-2 antikoerper, Mtap-2 antikoerper, xmap2 antikoerper, MGC53131 antikoerper, a730034c02 antikoerper, zgc:103474 antikoerper, zgc:113974 antikoerper, microtubule associated protein 2 antikoerper, microtubule-associated protein 2 antikoerper, microtubule associated protein 2 S homeolog antikoerper, MAP2 antikoerper, Map2 antikoerper, map2.S antikoerper, map2 antikoerper

Hintergrund:

Synonyms: MAP2(Phospho Thr1613/1619), MAP2 (phospho Thr1613/1619), p-MAP2 (phospho Thr1613/1619), MAP2(Phospho Thr1613/1619), MAP2(Phospho-Thr1613/1619), p-MAP2(Phospho-Thr1613/1619), DKFZp686I2148, Dendrite specific MAP, DKFZp686I2148, MAP 2, MAP-2, MAP2, MAP2_HUMAN, MAP2A, MAP2B, MAP2C, Microtubule associated protein 2, Microtubule-associated protein 2, Mtap 2.

Background: MAP2 is the major microtubule associated protein of brain tissue. There are three forms of MAP2, two are similarily sized with apparent molecular weights of 280 kDa (MAP2a and MAP2b) and the third with a lower molecular weight of 70 kDa (MAP2c). In the newborn rat brain, MAP2b and MAP2c are present, while MAP2a is absent. Between postnatal days 10 and 20, MAP2a appears. At the same time, the level of MAP2c drops by 10-fold. This change happens during the period when dendrite growth is completed and when neurons have reached their mature morphology. MAP2 is degraded by a Cathepsin D-like protease in the brain of aged rats. There is some indication that MAP2 is expressed at higher levels in some types of neurons than in other types. MAP2 is known to promote microtubule assembly and to form side-arms on microtubules. It also interacts with neurofilaments, actin, and other elements of the cytoskeleton.

Gen-ID: 4133

UniProt: P11137