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WWTR1 Antikörper (C-Term)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch WWTR1 in WB. Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN6972842

Kurzübersicht für WWTR1 Antikörper (C-Term) (ABIN6972842)

Target

Alle WWTR1 Antikörper anzeigen
WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))

Reaktivität

  • 34
  • 8
  • 4
  • 2
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 29
  • 5
Kaninchen

Klonalität

  • 29
  • 5
Polyklonal

Konjugat

  • 24
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser WWTR1 Antikörper ist unkonjugiert

Applikation

  • 27
  • 12
  • 4
  • 4
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB)
  • Bindungsspezifität

    • 5
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term

    Produktmerkmale

    The TAZ / WWTR1 (Transcriptional coactivator with PDZ-binding motif, WW domain-containing transcription regulator protein 1) gene encodes a protein that is a transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition. TAZ / WWTR1 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human samples.

    Aufreinigung

    Affinity Purified

    Immunogen

    TAZ / WWTR1 antibody was raised against a peptide corresponding to the C-terminal region of human TAZ / WWTR1.

    Isotyp

    IgG
  • Applikationshinweise

    Optimal working dilution should be determined by the investigator.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Buffer

    Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
  • Target

    WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))

    Andere Bezeichnung

    TAZ / WWTR1

    Molekulargewicht

    55 kDa

    NCBI Accession

    NP_056287

    Pathways

    Regulation of Lipid Metabolism by PPARalpha
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