TYROBP Antikörper (AA 60-100)

Produktnummer ABIN6945239

Der Kaninchen Monoklonal anti-TYROBP Antikörper (Klon 2F4) (ABIN6945239) detektiert spezifisch TYROBP in FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für TYROBP Antikörper (AA 60-100) (ABIN6945239)

Target: TYROBP (TYRO Protein tyrosine Kinase Binding Protein (TYROBP))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser TYROBP Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Klon: 2F4

Produktdetails anti-TYROBP Antikörper

Bindungsspezifität: AA 60-100

Verwendungszweck: TYROBP Recombinant Antibody

Kreuzreaktivität: Human

Aufreinigung: Purified by Protein A.

Immunogen: Synthetic peptide within human DAP12 aa 60-100.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow-Cyt(1:50-100)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu TYROBP

Target: TYROBP (TYRO Protein tyrosine Kinase Binding Protein (TYROBP))

Andere Bezeichnung: TYROBP

Hintergrund:

Synonyms: TYRO protein tyrosine kinase-binding protein, DNAX-activation protein 12, Killer-activating receptor-associated protein, KAR-associated protein, TYROBP, DAP12, KARAP

Background: TYROBP is a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70 kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. TYROBP Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin.

Gen-ID: 7305

UniProt: O43914