TYROBP Antikörper
Kurzübersicht für TYROBP Antikörper (ABIN306916)
Target
Alle TYROBP Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Verwendungszweck
- Rabbit anti Human DAP12
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Kreuzreaktivität
- Human, Maus
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Produktmerkmale
- DAP12 is a transmembrane adaptor protein that is non-covalently associated with several cell surface receptors on natural killer (NK), myeloid, and presumably neuronal cells (1,2). DAP12 contains an ITAM domain that preferentially recruits the protein tyrosine kinase Syk to initiate signal transduction (3). Deficiency of DAP12 results in reduced antigen presentation function by myeloid cells and defects in function of certain NK cell receptors in mice (4,5), as well as presenile dementia and bone cysts in humans (6).
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Aufreinigung
- Ammonium Sulfate Precipitation
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Applikationshinweise
- Antibody can be used for immunoprecipitation (2-4 μg/mg of protein lysate). Optimal concentration should be evaluated by serial dilutions.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- phosphate buffered saline with 0.08 % sodium azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
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- TYROBP (TYRO Protein tyrosine Kinase Binding Protein (TYROBP))
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Andere Bezeichnung
- DAP12
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Hintergrund
- TYRO protein tyrosine kinase-binding protein, DNAX-activation protein 12, Killer-activating receptor-associated protein, KARAP, TYROBP
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UniProt
- O43914
Target
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