KAP1 Antikörper
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- Target Alle KAP1 (TRIM28) Antikörper anzeigen
- KAP1 (TRIM28) (Tripartite Motif Containing 28 (TRIM28))
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Monoklonal
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Konjugat
- Dieser KAP1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Flow Cytometry (FACS)
- Kreuzreaktivität
- Human, Maus, Ratte
- Aufreinigung
- Purified by Protein A.
- Immunogen
- N terminus human KAP1
- Klon
- 7C5
- Isotyp
- IgG
- Top Product
- Discover our top product TRIM28 Primärantikörper
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- Applikationshinweise
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WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(ICC) 1:50-200
IHC() - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C for 12 months.
- Haltbarkeit
- 12 months
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- Target
- KAP1 (TRIM28) (Tripartite Motif Containing 28 (TRIM28))
- Andere Bezeichnung
- KAP1 (TRIM28 Produkte)
- Synonyme
- KAP1 antikoerper, RNF96 antikoerper, TF1B antikoerper, TIF1B antikoerper, TRIM28 antikoerper, kap1 antikoerper, rnf96 antikoerper, tf1b antikoerper, tif1b antikoerper, AA408787 antikoerper, KAP-1 antikoerper, KRIP-1 antikoerper, Tif1b antikoerper, Tif1beta antikoerper, Kap1 antikoerper, Krip1 antikoerper, TIF1BETA antikoerper, tripartite motif containing 28 antikoerper, tripartite motif containing 28 L homeolog antikoerper, tripartite motif-containing 28 antikoerper, TRIM28 antikoerper, trim28.L antikoerper, Trim28 antikoerper
- Hintergrund
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Synonyms: Transcription intermediary factor 1-beta, E3 SUMO-protein ligase TRIM28, KRAB-associated protein 1, KRAB-interacting protein 1, Nuclear corepressor KAP-1, RING finger protein 96, Tripartite motif-containing protein 28, TIF1-beta, KAP-1, KRIP-1, TRIM28
Background: Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteosomal degradation, the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors.
- Gen-ID
- 10155
- UniProt
- Q13263
- Pathways
- Hedgehog Signalweg, Positive Regulation of Response to DNA Damage Stimulus
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