Complement Factor H Antikörper

Produktnummer ABIN6943395

Produktdetails anti-Complement Factor H Antikörper

Target: Complement Factor H (CFH)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser Complement Factor H Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc))

Kreuzreaktivität: Human

Aufreinigung: Purified by Protein A.

Immunogen: Full length protein

Klon: 6F11

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
FCM 1:20-100
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu Complement Factor H

Target: Complement Factor H (CFH)

Andere Bezeichnung: Factor H (CFH Produkte)

Synonyme: AHUS1 antikoerper, AMBP1 antikoerper, ARMD4 antikoerper, ARMS1 antikoerper, CFHL3 antikoerper, FH antikoerper, FHL1 antikoerper, HF antikoerper, HF1 antikoerper, HF2 antikoerper, HUS antikoerper, Mud-1 antikoerper, NOM antikoerper, Sas-1 antikoerper, Sas1 antikoerper, Fh antikoerper, CFH antikoerper, im:7147412 antikoerper, si:ch211-207o17.2 antikoerper, fH antikoerper, armd4 antikoerper, arms1 antikoerper, cfh antikoerper, cfhl3 antikoerper, fhl1 antikoerper, hf1 antikoerper, hf2 antikoerper, hus antikoerper, complement factor H antikoerper, complement component factor h antikoerper, complement factor H-related protein 5 antikoerper, complement factor H L homeolog antikoerper, CFH antikoerper, Cfh antikoerper, cfh antikoerper, LOC100399888 antikoerper, LOC100733902 antikoerper, cfh.L antikoerper

Hintergrund:

Synonyms: Complement factor H, H factor 1, CFH, HF, HF1, HF2

Background: A glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self-markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed.

Gen-ID: 3075

UniProt: P08603

Pathways: Komplementsystem, Cellular Response to Molecule of Bacterial Origin