CHEK1 Antikörper (pSer286) (HRP)

Produktnummer ABIN6942551

Dieses Anti-CHEK1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CHEK1 in WB, ELISA, IHC (p) und IHC (fro). Geeignet für Maus.

Kurzübersicht für CHEK1 Antikörper (pSer286) (HRP) (ABIN6942551)

Target: CHEK1 (Checkpoint Kinase 1 (CHEK1))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CHEK1 Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-CHEK1 Antikörper (HRP)

Bindungsspezifität: pSer286

Kreuzreaktivität: Maus

Homologie: Human,Dog,Horse,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated Synthesised phosphopeptide derived from human CHEK1 around the phosphorylation site of Ser286.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu CHEK1

Target: CHEK1 (Checkpoint Kinase 1 (CHEK1))

Andere Bezeichnung: CHK1

Hintergrund:

Synonyms: Chk1 (phospho S286), p-Chk1 (phospho S286), Chk1 (Phospho-Ser286), CHEK1 (phospho Ser286), CHEK1 (phospho Ser286), p-CHEK1 (Ser286), Cell cycle checkpoint kinase, Checkpoint, S. pombe, homolog of, 1, Checkpoint kinase 1, Checkpoint kinase 1 homolog (S. pombe), CHEK 1, CHEK-1, CHEK1, Chk 1, Chk1, CHK1 checkpoint homolog (S. pombe), EC 2.7.11.1, rad27, Serine/threonine protein kinase Chk1, Serine/threonine-protein kinase CHK1, STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae), C85740, CHK1_HUMAN.

Background: The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2011].

Gen-ID: 1111

UniProt: O14757

Pathways: p53 Signalweg, Apoptose, Zellzyklus, DNA Reparatur