STAT5B Antikörper

Produktnummer ABIN6940671

Produktdetails anti-STAT5B Antikörper

Target: STAT5B (Signal Transducer and Activator of Transcription 5B (STAT5B))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser STAT5B Antikörper ist unkonjugiert

Applikation: ELISA, Coating (Coat)

Aufreinigung: Purified by Protein A/G

Immunogen: Recombinant full-length human STAT5B protein

Klon: STAT5B-2657

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Positive Control: Human spleen.

Known Application: ELISA (For coating use Ab at 1-5 μg/mL, order Ab without BSA) Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-80 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu STAT5B

Target: STAT5B (Signal Transducer and Activator of Transcription 5B (STAT5B))

Andere Bezeichnung: STAT5B (STAT5B Produkte)

Synonyme: STAT5 antikoerper, stat5 antikoerper, STAT5A antikoerper, STAT5B antikoerper, signal transducer and activator of transcription 5B antikoerper, signal transducer and activator of transcription 5B S homeolog antikoerper, Signal transducer and activator of transcription 5B antikoerper, STAT5B antikoerper, Stat5b antikoerper, stat5b.S antikoerper, LOC490969 antikoerper, sta5b antikoerper, LOC100566752 antikoerper, LOC100052954 antikoerper

Hintergrund: Signal transducer and activator of transcription 5A (Stat5a) and Stat5b, which share 96 % homology, undergo receptor tyrosine kinase or G protein-coupled receptor-dependent phosphorylation in response to cytokines or growth factors, and then form homo- or heterodimers that translocate to the nucleus, where they initiate transcription. Activation of Stat5a via IL-2, IL-3, IL-7/ GM-CSF, erythropoietin, thrombopoietin and growth hormones influences proliferation, differentiation and apoptosis in lymphohematopoietic cells. Phosphorylation of Stat5a at Ser127/Ser128 and Ser779 are contigent on ErbB-4-mediated activation of Stat5a. Activation of Stat5b via IL-2, IL-4, CSF-1 and growth hormones influences TCR signaling, apoptosis, adult mammary gland development and sexual dimorphism of liver gene expression. Stat5b is the major liver-expressed Stat5 form that has been shown to fuse with the retinoic acid receptor a gene in acute promyelocytic leukemias (APLL). Stat5a/b null mice have severely impaired lymphoid development and differentiation.

Molekulargewicht: 94kDa

Gen-ID: 6777

UniProt: P51692

Pathways: JAK-STAT Signalweg, RTK Signalweg, Response to Growth Hormone Stimulus, C21-Steroid Hormone Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Activated T Cell Proliferation