Ubiquitin B Antikörper (AA 1-119)
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- Target Alle Ubiquitin B (UBB) Antikörper anzeigen
- Ubiquitin B (UBB)
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Bindungsspezifität
- AA 1-119
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser Ubiquitin B Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Coating (Coat), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Spezifität
- Ubiquitin is a highly conserved and plays an essential role in the ubiquitin-proteasome pathway. In ubiquitination process, it is first activated by forming a thiol-ester complex with the activation component E1, which is then transferred to ubiquitin-carrier protein E2, followed by to ubiquitin ligase E3 for final delivery to epsilon-NH2 of the target protein lysine residue. IkB, p53, cdc25A, Bcl-2 etc. are shown as targets of ubiquitin-proteasome process as part of regulation of cell cycle progression, differentiation, cell stress response, and apoptosis. Moreover, ubiquitin have been reported to bind covalently with pathological inclusions which are resistant to degradation e.g. neurofibrillary tangles/paired helical filaments in Alzheimer's disease, Lewy bodies seen in Parkinson's disease, and Pick bodies found in Pick's disease etc.
- Kreuzreaktivität (Details)
- Human.
- Aufreinigung
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant fragment of human Ubiquitin protein (around aa 1-119) (exact sequence is proprietary)
- Klon
- UBB-2122
- Isotyp
- IgG1 kappa
- Top Product
- Discover our top product UBB Primärantikörper
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- Applikationshinweise
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Known_Application: ELISA (For coating, order Ab without BSA); Western Blot (1-2ug/ml); Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes); Optimal dilution for a specific application should be determined.
Positive_Control: HeLa or Jurkat cells. Alzheimer's Brain.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Konservierungsmittel
- Azide free
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Haltbarkeit
- 24 months
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- Target
- Ubiquitin B (UBB)
- Andere Bezeichnung
- UBB (UBB Produkte)
- Synonyme
- AL033289 antikoerper, Rps27a antikoerper, Uba52 antikoerper, Ubb2 antikoerper, Ubc antikoerper, UBC antikoerper, Ubiquitin antikoerper, UBB antikoerper, Ubi-p63E antikoerper, im:6892314 antikoerper, si:ch211-202a12.3 antikoerper, ubc antikoerper, zUBC antikoerper, zgc:172187 antikoerper, ubiquitin B antikoerper, ubiquitin C antikoerper, UBB antikoerper, Ubb antikoerper, UBC antikoerper, ubb antikoerper
- Hintergrund
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Epididymis secretory protein Li 50, Polyubiquitin B, RPS27A, UBA52, UBA80, UBB, UBC, UBCEP1, UBCEP2, Ubiquitin, Ubiquitin B,Ubiquitin (Autophagy Marker)
Cellular localisation: Cell Surface, Cytoplasmic and Nuclear - Molekulargewicht
- 9kDa
- Gen-ID
- 7314, 356190, 520348
- UniProt
- P62979, P62987, P62988
- Pathways
- Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Activation of Innate immune Response, Mitotic G1-G1/S Phases, DNA Replication, Toll-Like Receptors Cascades, Synthesis of DNA, Autophagie, EGFR Downregulation, Ubiquitin Proteasome Pathway
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