IFI16 Antikörper (AA 201-350) (Biotin)

Produktnummer ABIN687039

Dieses Anti-IFI16-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von IFI16 in WB, ELISA, IHC (p) und IHC (fro). Geeignet für Human.

Kurzübersicht für IFI16 Antikörper (AA 201-350) (Biotin) (ABIN687039)

Target: IFI16 (Interferon, gamma-Inducible Protein 16 (IFI16))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IFI16 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-IFI16 Antikörper (Biotin)

Bindungsspezifität: AA 201-350

Kreuzreaktivität: Human

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human IFI16

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu IFI16

Target: IFI16 (Interferon, gamma-Inducible Protein 16 (IFI16))

Andere Bezeichnung: I16/MNDA

Hintergrund:

Synonyms: Gamma-interferon-inducible protein i16, Interferon-inducible myeloid dferentiation transcriptional activator, A730048F03, D3, D3cDNA, i-d3, I16, I16B, I204, I205, i205a, i205b, NGIP1, MGC9466, Mnda, p204, PYHIN2.

Background: Interferon (IFN) Inducible 16 (IFI16) protein belongs to a family of HIN 200 human and mouse proteins. IFI16 is a nuclear protein comtaining regulatory domains such as DNA binding domain, transcriptional regulatory domain and DAPIN/PAAD domain. IFI16 has three isotypes A, B, and C (85-95 kDa), which arise as a result of mRNA alternative splicing. All are phosphorylated on serine and threonine residues and can homo and heterodimerize. Expression is restricted to the nuclei of hematopoietic cells, fibroblasts and epithelial cells. IFI16 expression in hematopoietic cells of myeloid lineage is tightly regulated and highly induced in the differentiation and proliferation of the cell. Due to its localization in the nucleus, regulation of protein expression, and ability to bind DNA, it is assumed that IFI16 has a role in transcription regulation of cell differentiation. In addition, it was found that IFI16 can act as a transcriptional repressor and is involved in regulation and activation of p53 in cancer cells.

Gen-ID: 3428

Pathways: Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Autophagie, Inflammasome