BAX Antikörper (pSer184)

Produktnummer ABIN682843

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch BAX in WB, IF, FACS, IHC (p) und IHC (fro). Es zeigt Reaktivität gegenüber Proben von Human. Es wurde in 5+ Publikationen zitiert.

Kurzübersicht für BAX Antikörper (pSer184) (ABIN682843)

Target: BAX (BCL2-Associated X Protein (BAX))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BAX Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-BAX Antikörper

Bindungsspezifität: pSer184

Verwendungszweck: phospho-Bax (Ser184) Polyclonal Antibody

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Cow,Sheep,Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human Bax around the phosphorylation site of Ser184

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB(1:300-5000),

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-BAX Antikörper (ABIN682843)

Park, Park, Kim, Kim, Yoon, Hur: "Berberine induces mitochondrial apoptosis of EBV-transformed B cells through p53-mediated regulation of XAF1 and GADD45α." in: International journal of oncology, Vol. 49, Issue 1, pp. 411-21, (2016) (PubMed).

Daverey, Agrawal: "Curcumin alleviates oxidative stress and mitochondrial dysfunction in astrocytes." in: Neuroscience, Vol. 333, pp. 92-103, (2016) (PubMed).

Gao, Zhou, Wang, Lew, Richards, Wang: "Urocortin-2 suppression of p38-MAPK signaling as an additional mechanism for ischemic cardioprotection." in: Molecular and cellular biochemistry, (2014) (PubMed).

Park, Kim, Kim, Kim, Lee, Cho, Lee, Hur: "Melphalan-induced apoptosis of EBV-transformed B cells through upregulation of TAp73 and XAF1 and nuclear import of XPA." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 191, Issue 12, pp. 6281-91, (2013) (PubMed).

Pereda: "[Histochemical study of the distribution of sialomucins in the oviducts and jelly coat of the oocytes of Rana pipiens. Behavior of the different layers of the coat in water]." in: Journal of embryology and experimental morphology, Vol. 24, Issue 1, pp. 1-12, (1971) (PubMed).

Details zu BAX

Target: BAX (BCL2-Associated X Protein (BAX))

Andere Bezeichnung: Bax

Hintergrund:

Synonyms: BCL2L4, Apoptosis regulator BAX, Bcl-2-like protein 4, Bcl2-L-4, BAX

Background: Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.

Gen-ID: 581

UniProt: Q07812

Pathways: p53 Signalweg, PI3K-Akt Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response