BAX Antikörper (pSer184)

Produktnummer ABIN682843

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch BAX in WB, ELISA, FACS und IHC (p). Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte und wurde in 5+ Publikationen erwähnt.

Kurzübersicht für BAX Antikörper (pSer184) (ABIN682843)

Target: BAX (BCL2-Associated X Protein (BAX))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BAX Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-BAX Antikörper

Bindungsspezifität: pSer184

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Cow,Sheep,Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human Bax around the phosphorylation site of Ser184

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-BAX Antikörper (ABIN682843)

Park, Park, Kim, Kim, Yoon, Hur: "Berberine induces mitochondrial apoptosis of EBV-transformed B cells through p53-mediated regulation of XAF1 and GADD45α." in: International journal of oncology, Vol. 49, Issue 1, pp. 411-21, (2016) (PubMed).

Daverey, Agrawal: "Curcumin alleviates oxidative stress and mitochondrial dysfunction in astrocytes." in: Neuroscience, Vol. 333, pp. 92-103, (2016) (PubMed).

Gao, Zhou, Wang, Lew, Richards, Wang: "Urocortin-2 suppression of p38-MAPK signaling as an additional mechanism for ischemic cardioprotection." in: Molecular and cellular biochemistry, (2014) (PubMed).

Park, Kim, Kim, Kim, Lee, Cho, Lee, Hur: "Melphalan-induced apoptosis of EBV-transformed B cells through upregulation of TAp73 and XAF1 and nuclear import of XPA." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 191, Issue 12, pp. 6281-91, (2013) (PubMed).

Pereda: "[Histochemical study of the distribution of sialomucins in the oviducts and jelly coat of the oocytes of Rana pipiens. Behavior of the different layers of the coat in water]." in: Journal of embryology and experimental morphology, Vol. 24, Issue 1, pp. 1-12, (1971) (PubMed).

Details zu BAX

Target: BAX (BCL2-Associated X Protein (BAX))

Andere Bezeichnung: Bax

Hintergrund:

Synonyms: BCL2L4, Apoptosis regulator BAX, Bcl-2-like protein 4, Bcl2-L-4, BAX

Background: Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.

Gen-ID: 581

UniProt: Q07812

Pathways: p53 Signalweg, PI3K-Akt Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response