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PCNA Antikörper (AA 185-261)

Dieses Anti-PCNA-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PCNA in WB, ELISA, FACS, IHC (p), IF (p), IF (cc) und IHC (fro). Geeignet für Human, Maus, Ratte, Huhn, Kaninchen und Schaf. Dieses Primary Antibody wurde in 10+ Publikationen zitiert.
Produktnummer ABIN672756

Kurzübersicht für PCNA Antikörper (AA 185-261) (ABIN672756)

Target

Alle PCNA Antikörper anzeigen
PCNA (Proliferating Cell Nuclear Antigen (PCNA))

Reaktivität

  • 243
  • 165
  • 164
  • 54
  • 31
  • 30
  • 29
  • 22
  • 19
  • 19
  • 18
  • 17
  • 11
  • 10
  • 6
  • 5
  • 5
  • 5
  • 5
  • 4
  • 4
  • 4
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Human, Maus, Ratte, Huhn, Kaninchen, Schaf

Wirt

  • 142
  • 117
  • 3
Kaninchen

Klonalität

  • 139
  • 122
  • 1
Polyklonal

Konjugat

  • 143
  • 17
  • 11
  • 8
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser PCNA Antikörper ist unkonjugiert

Applikation

  • 218
  • 80
  • 67
  • 66
  • 64
  • 56
  • 54
  • 45
  • 40
  • 39
  • 14
  • 12
  • 5
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • Bindungsspezifität

    • 16
    • 16
    • 15
    • 15
    • 14
    • 14
    • 12
    • 9
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 185-261

    Kreuzreaktivität

    Huhn, Human, Maus, Kaninchen, Ratte, Schaf

    Homologie

    Dog,Cow

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human PCNA

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    Haltbarkeit

    12 months
  • Hu, Zuo, Li, Wang, Peng, Fang, Cui, Gao, Song, Zhou, Chen: "The molecular mechanism of cell cycle arrest in the Bursa of Fabricius in chick exposed to Aflatoxin B 1." in: Scientific reports, Vol. 8, Issue 1, pp. 1770, (2018) (PubMed).

    He, Bian, Ma, Wang, Wang, Zhao: "Long non-coding RNA SPRY4-IT1 promotes the proliferation and invasion of U251 cells through upregulation of SKA2." in: Oncology letters, Vol. 15, Issue 3, pp. 3977-3984, (2018) (PubMed).

    Yin, Jiang, Peng, Cui, Zhou, He, Zuo, Ouyang, Fan, Fang: "The molecular mechanism of G2M cell cycle arrest induced by AFB1 in the jejunum." in: Oncotarget, Vol. 7, Issue 24, pp. 35592-35606, (2016) (PubMed).

    Bi, Wang, Yang, Li, Liang, Han: "Effects of autologous bone marrow-derived stem cell mobilization on acute tubular necrosis and cell apoptosis in rats." in: Experimental and therapeutic medicine, Vol. 10, Issue 3, pp. 851-856, (2015) (PubMed).

    Li, Zhao, Wang, Chen, Lin, Zhu, Zheng, Wu, Cheng, Li, Bai, Fan, Liu: "Urotensin II promotes atherosclerosis in cholesterol-fed rabbits." in: PLoS ONE, Vol. 9, Issue 4, pp. e95089, (2015) (PubMed).

    Sun, Yang, Luo, Wang, Chen, Zhang, Wang, Li: "Thyroid hormone inhibits the proliferation of piglet Sertoli cell via PI3K signaling pathway." in: Theriogenology, (2014) (PubMed).

    Song, Yan, An, Hao, Guo, Zhang, Li, Li, Sun: "Potential contribution of SOCC to cerebral vasospasm after experimental subarachnoid hemorrhage in rats." in: Brain research, Vol. 1517, pp. 93-103, (2013) (PubMed).

    Chen, Shi, Liu, Fang, Zhang, Zhao: "Targeting SPARC by lentivirus-mediated RNA interference inhibits cervical cancer cell growth and metastasis." in: BMC cancer, Vol. 12, pp. 464, (2012) (PubMed).

  • Target

    PCNA (Proliferating Cell Nuclear Antigen (PCNA))

    Andere Bezeichnung

    PCNA

    Hintergrund

    Synonyms: ATLD2, Proliferating cell nuclear antigen, PCNA, Cyclin

    Background: Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.

    Gen-ID

    5111

    UniProt

    P12004

    Pathways

    Telomere Maintenance, DNA Reparatur, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Autophagie
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