Cyclin D3 Antikörper (AA 121-220) (HRP)
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- Target Alle Cyclin D3 (CCND3) Antikörper anzeigen
- Cyclin D3 (CCND3)
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Bindungsspezifität
- AA 121-220
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Reaktivität
- Human, Kaninchen
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Cyclin D3 Antikörper ist konjugiert mit HRP
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Kreuzreaktivität
- Human, Kaninchen
- Homologie
- Mouse,Rat,Dog,Cow,Pig
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Cyclin D3
- Isotyp
- IgG
- Top Product
- Discover our top product CCND3 Primärantikörper
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- Applikationshinweise
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WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Handhabung
- Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- Cyclin D3 (CCND3)
- Andere Bezeichnung
- Cyclin D3 (CCND3 Produkte)
- Synonyme
- zgc:103502 antikoerper, CCND3 antikoerper, 9230106B05Rik antikoerper, AA682053 antikoerper, AL024085 antikoerper, AW146355 antikoerper, C78795 antikoerper, cyclin D3 antikoerper, ccnd3 antikoerper, CCND3 antikoerper, Ccnd3 antikoerper
- Hintergrund
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Synonyms: G1/S-specific cyclin-D3, CCND3
Background: Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
- Gen-ID
- 896
- UniProt
- P30281
- Pathways
- Zellzyklus, Mitotic G1-G1/S Phases, Glycosaminoglycan Metabolic Process
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