SQSTM1 Antikörper (pSer28)

Produktnummer ABIN6655164

Hersteller Produkt- Nr.: 600-401-x20

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SQSTM1 in WB und ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für SQSTM1 Antikörper (pSer28) (ABIN6655164)

Target: SQSTM1 (Sequestosome 1 (SQSTM1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SQSTM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-SQSTM1 Antikörper

Bindungsspezifität: pSer28

Hersteller Produkt- Nr.: 600-401-x20

Hersteller: Rockland

Verwendungszweck: p62 Phospho S28 Antibody

Kreuzreaktivität (Details): Anti-Phospho-Ser28 p62 Antibody is directed against p62 protein phosphorylated at S28.

Aufreinigung: The antibody was prepared from monospecific antiserum by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide and non-specific peptide to remove any unwanted reactivities.

Sterilität: Sterile filtered

Immunogen: Anti-Phospho-Ser28 p62 Antibody was produced in rabbits by repeated immunizations with a synthetic phospho-peptide corresponding to amino acid residues surrounding the phospho-Ser28 of human p62 conjugated to KLH.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

ELISA_Dilution: 1:50,00

Western_Blot_Dilution: 1:500

Kommentare:

Anti-Phospho-Ser28 p62 Antibody is tested for Western Blots and is specific for the ~48 kDa p62 protein phosphorylated at Ser28. Specific conditions for reactivity should be optimized by the end user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Preservative: None

Konservierungsmittel: Without preservative

Lagerung: -20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening in undiluted aliquots. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.

Haltbarkeit: 12 months

Details zu SQSTM1

Target: SQSTM1 (Sequestosome 1 (SQSTM1))

Andere Bezeichnung: SQSTM1

Hintergrund:

Synonyms: Sequestosome-1, EBI3-associated protein of 60 kDa, EBIAP, p60, Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, Ubiquitin-binding protein p63

Background: p62, also known as sequestosome1 (SQSTM1), is a shuttle protein transporting polyubiquitinated proteins for both proteasomal and lysosomal degradation. p62 is an integral component of inclusions in brains of various neurodegenerative disorders, including Alzheimer disease (AD) neurofibrillary tangles (NFTs) and Lewy bodies in Parkinson disease. p62 plays an important role in the protection of cells from the toxicity of misfolded proteins by enhancing aggregate formation especially in the later stages. Phosphorylation of Ser28 has recently been demonstrated to be related to the pathogenesis of Parkinson's disease. p62 pS28 Antibody is ideal for researchers interested in neuroscience research.

Gene Name: SQSTM1

Gen-ID: 8878

NCBI Accession: NP_003891

UniProt: Q13501

Pathways: NF-kappaB Signalweg, Neurotrophin Signalübertragung, Autophagie