Synonyms: Highly similar to rap1/rap2 interacting protein,OTTHUMP00000223586,OTTHUMP00000223587,Regulation of G protein signaling 14,Regulator of G protein signaling 14,Regulator of G protein signalling 14,Regulator of G-protein signaling 14,RGS 14,RGS14,RGS14
Background: This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.