RGS14 Antikörper (AA 230-510)

Produktnummer ABIN7167592

Produktdetails anti-RGS14 Antikörper

Target: RGS14 (Regulator of G-Protein Signaling 14 (RGS14))

Bindungsspezifität: AA 230-510

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RGS14 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: Antigen Affinity Purified

Immunogen: Recombinant Human Regulator of G-protein signaling 14 protein (230-510AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu RGS14

Target: RGS14 (Regulator of G-Protein Signaling 14 (RGS14))

Andere Bezeichnung: RGS14 (RGS14 Produkte)

Synonyme: RPIP1 antikoerper, MGC80558 antikoerper, RGS14 antikoerper, rgs14 antikoerper, wu:fi04g12 antikoerper, regulator of G protein signaling 14 antikoerper, regulator of G-protein signaling 14 antikoerper, regulator of G-protein signaling 14 L homeolog antikoerper, regulator of G-protein signalling 14 antikoerper, regulator of G protein signaling 14a antikoerper, RGS14 antikoerper, Rgs14 antikoerper, rgs14.L antikoerper, rgs14 antikoerper, rgs14a antikoerper

Hintergrund:

Background: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o) alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation, a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory.

Aliases: Highly similar to rap1/rap2 interacting protein antibody, OTTHUMP00000223586 antibody, OTTHUMP00000223587 antibody, Regulation of G protein signaling 14 antibody, Regulator of G protein signaling 14 antibody, Regulator of G protein signalling 14 antibody, Regulator of G-protein signaling 14 antibody, RGS 14 antibody, RGS14 antibody, RGS14_HUMAN antibody

UniProt: O43566

Pathways: Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Platelet-derived growth Factor Receptor Signaling