Synonyms: CIS-4,CIS4,Cish4,Cytokine inducible SH2 protein 4,Cytokine-inducible SH2 protein 4,HSPC060,SOCS-4,SOCS-6,SOCS4,Socs6,SOCS6,SSI4,STAI4,STAT induced STAT inhibitor 4,STAT4,STATI4,Suppressor of cytokine signaling 4,Suppressor of cytokine signaling 6
Background: The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines.