Synonyms: 1 phosphatidylinositol 4,5 bisphosphate phosphodiesterase beta 1,1-phosphatidyl-D-myo-inositol-4,5-bisphosphate,1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1,EIEE12,Inositoltrisphosphohydrolase,Monophosphatidylinositol phosphodiesterase,Phosphb,Phosphoinositidase C,Phosphoinositide phospholipase C,Phosphoinositide phospholipase C-beta 1,Phosphoinositide phospholipase C-beta-1,Phospholipase C beta 1 (phosphoinositide-specific),Phospholipase C I,Phospholipase C-beta-1,Phospholipase C-I,PI PLC,PLC 1,PLC beta 1,PLC I,PLC-154,PLC-beta-1,PLC-I,PLC154,Plcb,Plcb1,Plcb1 protein ,PLCB1,PLCbeta1,Triphosphoinositide phosphodiesterase
Background: The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene.