Synonyms: subunit B'',KIAA0044 ,MGC2184 ,Phosphotyrosyl phosphatase activator,PP2A,PP2A phosphatase activator ,PP2A subunit B',PP2A subunit B' isoform PR53,PP2A subunit B' PR53 isoform ,PPP2R4,PR53 ,PR53 isoform,Protein phosphatase 2, regulatory subunit B-prime,Protein phosphatase 2A activator regulatory subunit 4,Protein phosphatase 2A regulatory subunit B' (PR 53),PTPA,PTPA,Serine/threonine protein phosphatase 2A regulatory subunit B' ,Serine/threonine-protein phosphatase 2A activator,Serine/threonine-protein phosphatase 2A regulatory subunit 4,Serine/threonine-protein phosphatase 2A regulatory subunit B''
Background: Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms.