Synonyms: 26S protease regulatory subunit 8,26S proteasome AAA-ATPase subunit RPT6,Cim3,MSUG1 protein,p45,p45/SUG,Proteasome 26S ATPase subunit 5,Proteasome 26S subunit ATPase 5,Proteasome prosome macropain 26S subunit ATPase 5,Proteasome subunit p45,PRS8,PSMC5,Rpt6,S8,SUG1,Tat binding protein homolog 10,TBP10,Thyroid hormone receptor interacting protein 1,Thyroid hormone receptor-interacting protein 1,Thyroid receptor interactor 1,TRIP1,TRIP1(SUG1)
Background: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene.