PSMC5 Antikörper (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 5)

Details for Product anti-PSMC5 Antibody No. ABIN6568676
Target
Reaktivität
Human, Maus, Ratte
33
25
23
5
5
4
4
3
3
3
3
3
2
1
1
1
1
Wirt
Kaninchen
26
6
1
Klonalität
Polyklonal
Konjugat
Dieser PSMC5 Antikörper ist unkonjugiert
2
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (IF), Western Blotting (WB)
25
9
8
7
5
4
3
3
2
2
1
Optionen
Immunogen Recombinant protein of human PSMC5
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung PSMC5 (PSMC5 Antibody Abstract)
Hintergrund

Synonyms: 26S protease regulatory subunit 8,26S proteasome AAA-ATPase subunit RPT6,Cim3,MSUG1 protein,p45,p45/SUG,Proteasome 26S ATPase subunit 5,Proteasome 26S subunit ATPase 5,Proteasome prosome macropain 26S subunit ATPase 5,Proteasome subunit p45,PRS8,PSMC5,Rpt6,S8,SUG1,Tat binding protein homolog 10,TBP10,Thyroid hormone receptor interacting protein 1,Thyroid hormone receptor-interacting protein 1,Thyroid receptor interactor 1,TRIP1,TRIP1(SUG1)

Background: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht

Observed_MW: 46kDa

Calculated_MW: 44kDa/45kDa

Gen-ID 5705
UniProt P62195
Pathways Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA
Applikations-hinweise WB 1:500 - 1:2000 IF 1:50 - 1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 5 (PSMC5) antibody (ABIN6568676) Immunofluorescence analysis of MCF-7 cells using PSMC5 antibody.
Image no. 2 for anti-Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 5 (PSMC5) antibody (ABIN6568676) Western blot analysis of extracts of various cell lines, using PSMC5 antibody.