PSMC5 Antikörper (Center)

Produktnummer ABIN2856087

Produktdetails anti-PSMC5 Antikörper

Target: PSMC5 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 5 (PSMC5))

Bindungsspezifität: Center

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PSMC5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Kreuzreaktivität: Zebrafisch (Danio rerio), Xenopus laevis, Xenopus tropicalis, Rhesusaffen, Schimpanse, Rind (Kuh)

Kreuzreaktivität (Details): Zebrafish (100 %), Xenopus laevis (100 %), Xenopus Tropicalis (100 %), Rhesus Monkey (100 %), Chimpanzee (100 %), Bovine (100 %)

Produktmerkmale: Rabbit Polyclonal antibody to PSMC5 (proteasome (prosome, macropain) 26S subunit, ATPase, 5)
PSMC5 antibody

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein encompassing a sequence within the center region of human PSMC5. The exact sequence is proprietary.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Suggested dilution Reference ICC/IF 1:100-1:1000* IHC (Formalin-fixed paraffin-embedded sections) 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceICC/IF1:100-1:1000* IHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000* Western blot1:500-1:3000*

Kommentare:

Positive Control: A431 , HepG2 , Neuro2A , GL261 , C8D30 , PC-12

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Details zu PSMC5

Target: PSMC5 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 5 (PSMC5))

Andere Bezeichnung: PSMC5 (PSMC5 Produkte)

Synonyme: mSUG1 antikoerper, S8 antikoerper, SUG-1 antikoerper, SUG1 antikoerper, TBP10 antikoerper, TRIP1 antikoerper, p45 antikoerper, p45/SUG antikoerper, wu:fa14g03 antikoerper, wu:fb23a11 antikoerper, zgc:92464 antikoerper, sug-1 antikoerper, sug1 antikoerper, tbp10 antikoerper, Sug1 antikoerper, PSMC5 antikoerper, xsug1 antikoerper, protease (prosome, macropain) 26S subunit, ATPase 5 antikoerper, proteasome 26S subunit, ATPase 5 antikoerper, proteasome 26S subunit, ATPase 5 L homeolog antikoerper, proteasome 26S subunit, ATPase 5 S homeolog antikoerper, Psmc5 antikoerper, PSMC5 antikoerper, psmc5 antikoerper, psmc5.L antikoerper, psmc5.S antikoerper

Hintergrund: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha.

Cellular Localization: Cytoplasm (Potential) , Nucleus

Molekulargewicht: 46 kDa

Gen-ID: 5705

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway