RNASEH2A Antikörper (Ribonuclease H2, Subunit A)

Details for Product anti-RNASEH2A Antibody No. ABIN6568584
Target
Reaktivität
Ratte
23
8
7
4
2
2
2
1
1
1
1
1
Wirt
Kaninchen
20
4
Klonalität
Polyklonal
Applikation
Western Blotting (WB)
24
13
11
6
4
3
1
1
1
1
Optionen
Immunogen Recombinant protein of human RNASEH2A
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung RNASEH2A (RNASEH2A Antibody Abstract)
Hintergrund

Synonyms: AGS4 ,Aicardi Goutieres syndrome 4 protein,EC 3.1.26.4,JUNB,Ribonuclease HI large subunit,Ribonuclease HI subunit A,RNase H(35),RNase H2 subunit A,RNase HI large subunit,RNASEH2A,RNASEHI,RNHIA,RNHL

Background: The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.

Molekulargewicht

Observed_MW: 33kDa

Calculated_MW: 33kDa

Gen-ID 10535
UniProt O75792
Applikations-hinweise WB 1:500 - 1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Ribonuclease H2, Subunit A (RNASEH2A) antibody (ABIN6568584) Western blot analysis of extracts of various cell lines, using RNASEH2A antibody.