Synonyms: IFI16,Gamma interferon inducible protein 16,Gamma-interferon-inducible protein Ifi16,IF16,Ifi204,IFNGIP1,interferon activated gene 204,Interferon gamma induced protein IFI 16,Interferon gamma inducible protein 16,Interferon-inducible myeloid differentiation transcriptional activator,p204,PYHIN2
Background: This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.