CASC5 Antikörper (Cancer Susceptibility Candidate 5) Primary Antibody
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- Target
- Reaktivität
- Human
- Wirt
- Kaninchen
- Klonalität
- Polyklonal
- Konjugat
- Dieser CASC5 Antikörper ist unkonjugiert
- Applikation
- Western Blotting (WB)
- Aufreinigung
- Affinity purification
- Immunogen
- Recombinant Protein of human CASC5
- Isotyp
- IgG
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- Applikationshinweise
- WB 1:500 - 1:2000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1 mg/mL
- Buffer
- Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- Andere Bezeichnung
- CASC5 (CASC5 Antibody Abstract)
- Hintergrund
Synonyms: Protein D40/AF15q14,AF15Q14,ALL1 fused gene from chromosome 15q14,Blinkin bub linking kinetochore protein,Cancer susceptibility candidate 5,Cancer susceptibility candidate gene 5 protein,Cancer/testis antigen 29,CT29,D40,hKNL 1,hSpc105,KIAA1570,Kinetochore null 1 homolog,Kinetochore null protein 1,Kinetochore scaffold 1,KNL1
Background: The protein encoded by this gene is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. The encoded protein functions as a scaffold for proteins that influence the spindle assembly checkpoint during the eukaryotic cell cycle and it interacts with at least five different kinetochore proteins and two checkpoint kinases. In adults, this gene is predominantly expressed in normal testes, various cancer cell lines and primary tumors from other tissues and is ubiquitously expressed in fetal tissues. This gene was originally identified as a fusion partner with the mixed-lineage leukemia (MLL) gene in t(11,15)(q23,q14). Mutations in this gene cause autosomal recessive primary microcephaly-4 (MCPH4). Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described but their biological validity has not been confirmed.
- Molekulargewicht
Observed_MW: 300kDa
Calculated_MW: 195kDa/205kDa/262kDa/265kDa
- Gen-ID
- 57082
- UniProt
- Q8NG31
- Pathways
- Maintenance of Protein Location, Autophagie