CASC5 Produkte
(Cancer Susceptibility Candidate 5 (CASC5))
Kategorien
The protein encoded by this gene is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. The encoded protein functions as a scaffold for proteins that influence the spindle assembly checkpoint during the eukaryotic cell cycle and it interacts with at least five different kinetochore proteins and two checkpoint kinases. In adults, this gene is predominantly expressed in normal testes, various cancer cell lines and primary tumors from other tissues and is ubiquitously expressed in fetal tissues. This gene was originally identified as a fusion partner with the mixed-lineage leukemia (MLL) gene in t(11\;15)(q23\;q14). Mutations in this gene cause autosomal recessive primary microcephaly-4 (MCPH4). Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jan 2013].
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Ausgewählte CASC5 Kategorien
CASC5 Antikörper
High quality antibodies with extensive validation data.
CASC5 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene CASC5 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Rat
Applikation
WB, IHC
Validierungen
- (3)
Kat. Nr.
ABIN7256628
Menge
200 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, IF
Validierungen
- (3)
Kat. Nr.
ABIN6137952
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validierungen
- (1)
Kat. Nr.
ABIN760391
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene CASC5 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1348085
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Insect Cells
Validierungen
- (1)
Kat. Nr.
ABIN3135614
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7420573
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren CASC5 Produkten
: "Lateral attachment of kinetochores to microtubules is enriched in prometaphase rosette and facilitates chromosome alignment and bi-orientation establishment." in: Scientific reports, Vol. 8, Issue 1, pp. 3888, (2019) (PubMed).: "TRAMM/TrappC12 plays a role in chromosome congression, kinetochore stability, and CENP-E recruitment." in: The Journal of cell biology, Vol. 209, Issue 2, pp. 221-34, (2015) (PubMed).
: "ASPP1/2-PP1 complexes are required for chromosome segregation and kinetochore-microtubule attachments." in: Oncotarget, Vol. 6, Issue 39, pp. 41550-65, (2015) (PubMed).
Synonyme und alternative Namen zu CASC5
kinetochore scaffold 1 (KNL1), kinetochore scaffold 1 (Knl1), Kinetochore null protein 1 (knl-1), 2310043D08Rik, 5730505K17Rik, AF15Q14, CT29, D40, hKNL-1, hSpc105, KNL1, PPP1R55, Rad51, Spc7Bezeichner auf Proteinebene für CASC5
- cancer susceptibility candidate 5
- ALL1-fused gene from chromosome 15q14 protein
- blinkin, bub-linking kinetochore protein
- cancer susceptibility candidate gene 5 protein
- cancer/testis antigen 29
- kinetochore null 1 homolog
- kinetochore-null protein 1
- protein CASC5
- protein phosphatase 1, regulatory subunit 55
- RAD51 homolog
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