PDK3 Antikörper (Pyruvate Dehydrogenase Kinase, Isozyme 3)

Details for Product anti-PDK3 Antibody No. ABIN6567502
Target
Reaktivität
Human
54
35
8
4
4
3
3
3
3
3
2
2
1
1
Wirt
Kaninchen
68
7
Klonalität
Polyklonal
Konjugat
Dieser PDK3 Antikörper ist unkonjugiert
7
6
6
5
5
5
Applikation
Western Blotting (WB)
69
51
25
3
3
2
2
1
1
Optionen
Immunogen Recombinant protein of human PDK3
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung PDK3 (PDK3 Antibody Abstract)
Hintergrund

Synonyms: [Pyruvate dehydrogenase [lipoamide] kinase isozyme 3 mitochondrial,[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3,CMTX6,GS1-358P8.4,mitochondrial,PDK3,PDK3,Pyruvate dehydrogenase kinase isoenzyme 3,Pyruvate dehydrogenase kinase isoform 3,Pyruvate dehydrogenase kinase isozyme 3,Pyruvate dehydrogenase lipoamide kinase isozyme 3 mitochondrial

Background: The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht

Observed_MW: 47kDa

Calculated_MW: 46kDa/48kDa

Gen-ID 5165
UniProt Q15120
Pathways PI3K-Akt Signalweg, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process
Applikations-hinweise WB 1:500 - 1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Pyruvate Dehydrogenase Kinase, Isozyme 3 (PDK3) antibody (ABIN6567502) Western blot analysis of extracts of SH-SY5Y cells, using PDK3 Antibody.