Synonyms: C lectin type II protein,CD159 antigen like family member A,CD159 antigen-like family member A,CD159a,CD159a antigen,Killer cell lectin like receptor subfamily C member 1,KLRC1,MGC13374,MGC59791,Natural killer cell lectin,Natural killer cell protein group 2-A1,Natural killer cell receptor NKG2A,Natural killer group protein 2,NK cell receptor A,NKG2 1/B activating NK receptor,NKG2 A,NKG2 A/B activating NK receptor,NKG2 A/B type II integral membrane protein,NKG2 A/NKG2 B type II integral membrane protein,NKG2,NKG2 B,NKG2-1/B activating NK receptor,NKG2-A/B-activating NK receptor,NKG2-A/NKG2-B type II integral membrane protein,NKG2A,NKG2A,NKG2B,rNKG2A
Background: Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.