STAT3 Antikörper (Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor))

Details for Product anti-STAT3 Antibody No. ABIN6567277
Target
Reaktivität
Human, Affe, Maus, Ratte
320
179
161
29
22
19
18
8
8
8
5
5
5
4
3
2
1
1
1
Wirt
Kaninchen
265
60
16
2
2
1
Klonalität
Polyklonal
Konjugat
Dieser STAT3 Antikörper ist unkonjugiert
30
19
14
11
10
9
8
8
8
8
8
8
2
2
2
2
2
2
2
1
1
1
Applikation
Western Blotting (WB)
262
150
110
49
43
37
35
29
27
10
9
7
4
4
3
3
3
2
2
1
1
1
1
1
Optionen
Immunogen Recombinant protein of human STAT3
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung STAT3 (STAT3 Antibody Abstract)
Hintergrund

Synonyms: 1110034C02Rik,Acute Phase Response Factor,Acute-phase response factor,ADMIO,APRF,AW109958,DNA binding protein APRF,FLJ20882,HIES,MGC16063,Signal transducer and activator of transcription 3 (acute phase response factor),Signal transducer and activator of transcription 3,STAT 3,Stat3,STAT3

Background: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Molekulargewicht

Observed_MW: 100kDa

Calculated_MW: 83kDa/87kDa/88kDa

Gen-ID 6774
UniProt P40763
Pathways JAK-STAT Signalweg, RTK Signalweg, Interferon-gamma Pathway, Neurotrophin Signalübertragung, Dopaminergic Neurogenesis, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Stem Cell Maintenance, Hepatitis C, Protein targeting to Nucleus, Feeding Behaviour, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor
Applikations-hinweise WB 1:500 - 1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) (STAT3) antibody (ABIN6567277) Western blot analysis of extracts of various cell lines, using STAT3 antibody.