Synonyms: hMAD1,HsMAD1,MAD1,MAD1 mitotic arrest deficient like 1 (yeast),MAD1-like protein 1,MAD1L1,MD1L1,Mitotic arrest deficient 1,Mitotic arrest deficient 1-like protein 1,Mitotic checkpoint MAD1 protein homolog,Mitotic spindle assembly checkpoint protein MAD1,PIG9,Tax binding protein 181,Tax-binding protein 181,TP53I9,Tumor protein p53 inducible protein 9,TXBP181
Background: MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Alternative splicing results in multiple transcript variants.