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MAD1L1 Antikörper (MAD1 Mitotic Arrest Deficient-Like 1) Primary Antibody

MAD1L1 Reaktivität: Human FACS, IP, WB Wirt: Maus Monoclonal 9B10 unconjugated
Pubmed (1 reference)
Produktnummer ABIN129517
$658.50
Zzgl. Versandkosten $45.00 und $20.00 Trockeneis
100 μg
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 1 bis 2 Werktagen
  • Target Alle MAD1L1 Antikörper anzeigen
    MAD1L1
    Reaktivität
    • 41
    • 16
    • 14
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 38
    • 3
    • 1
    Maus
    Klonalität
    • 39
    • 3
    Monoklonal
    Konjugat
    • 23
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MAD1L1 Antikörper ist unkonjugiert
    Applikation
    • 34
    • 21
    • 8
    • 5
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB)
    Produktmerkmale
    Concentration Definition: by UV absorbance at 280 nm
    Immunogen
    This protein A purified monoclonal antibody was produced by repeated immunizations with full-length recombinant human MAD1L1 protein.
    Immunogentype:Recombinant
    Klon
    9B10
    Isotyp
    IgG
  • Applikationshinweise
    This protein A purified antibody has been tested for use in flow cytometry, immunoprecipitation, immunofluorescence and western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a predominant band at ~ 24 kDa corresponding to full-length protein by western blotting in the appropriate cell lysate or extract.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1.0 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
  • Sikorski, Mehta, Inngjerdingen, Thakor, Kling, Kalina, Nyman, Stensland, Zhou, de Souza, Holden, Stuchly, Templin, Lund-Johansen: "A high-throughput pipeline for validation of antibodies." in: Nature methods, Vol. 15, Issue 11, pp. 909-912, (2019) (PubMed).

  • Target
    MAD1L1
    Andere Bezeichnung
    MAD1L1 (MAD1L1 Produkte)
    Synonyme
    MAD1, PIG9, TP53I9, TXBP181, AI173502, AW550425, Mad1, zgc:56571, MAD1-like protein 1, mitotic arrest deficient 1 like 1, MAD1 mitotic arrest deficient like 1, MAD1 mitotic arrest deficient 1-like 1, deafness, autosomal recessive 19, MAD1L1, Mad1l1, mad1l1, DFNB19
    Hintergrund
    MAD1L1 (also called mitotic spindle assembly checkpoint protein, MAD1A, MAD1-like 1 and HsMAD1) is a component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD1L1 has a role in the correct positioning of the septum and is required for anchoring MAD2L1 to the nuclear periphery.   MAD1L1 forms a homodimer and also heterodimerizes with MAD2L1 in order to form a tetrameric MAD1L1-MAD2L1 core complex. Perturbation of the original MAD1L1-MAD2L1 structure by the spindle checkpoint may decrease MAD2L1 affinity for MAD1L1. CDC20 can compete with MAD1L1 for MAD2L1 binding, until the attachment and/or tension dampen the checkpoint signal, preventing further release of MAD2L1 on to CDC20.  MAD1L1 is also able to interact with the BUB1/BUB3 complex and the viral Tax protein.   MAD1L1 is a nuclear protein that is seen to move from the beginning to the end of mitosis from a diffusely nuclear distribution to the centrosome, to the spindle midzone and finally to the midbody.  Multiple isoforms may exist for this protein (MAD1L1 and MAD1L2).  MAD1L1 is induced by TP53 and is phosphorylated by BUB1. MAD1L1 is hyperphosphorylated in late S through M phases or after mitotic spindle damage.  Defects in MAD1L1 are involved in the development and/or progression of various types of cancer.
    Synonyms: Mitotic arrest deficient 1 antibody, Mitotic checkpoint MAD1 protein homolog antibody, Mitotic spindle assembly checkpoint protein MAD1 antibody, PIG9 antibody, Tax binding protein 181 antibody
    Gen-ID
    8379
    UniProt
    Q9Y6D9
    Pathways
    M Phase
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