MSH6 Antikörper (MutS Homolog 6 (E. Coli))

Details for Product anti-MSH6 Antibody No. ABIN6566722
Target
Reaktivität
Human, Affe, Maus
76
40
32
8
2
2
1
1
1
Wirt
Kaninchen
54
20
2
Klonalität
Polyklonal
Konjugat
Dieser MSH6 Antikörper ist unkonjugiert
4
3
3
3
2
2
2
2
2
1
1
1
1
1
Applikation
Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
47
28
27
21
20
13
8
6
4
4
4
4
3
2
1
1
1
Optionen
Immunogen Recombinant protein of human MSH6
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung MSH6 (MSH6 Antibody Abstract)
Hintergrund

Synonyms: DNA mismatch repair protein Msh6,G/T mismatch binding protein,G/T mismatch-binding protein,GTBP,GTMBP,hMSH6,HNPCC 5,HNPCC5,HSAP,MSH 6,MSH6,MSH6,mutS (E. coli) homolog 6,MutS alpha 160 kDa subunit,MutS homolog 6 (E. coli),mutS homolog 6,MutS-alpha 160 kDa subunit,p160,Sperm associated protein

Background: This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described.

Molekulargewicht

Observed_MW: 160kDa

Calculated_MW: 119kDa/120kDa/137kDa/152kDa

Gen-ID 2956
UniProt P52701
Pathways DNA Reparatur, Chromatin Binding, Production of Molecular Mediator of Immune Response
Applikations-hinweise WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:20 - 1:100
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-MutS Homolog 6 (E. Coli) (MSH6) antibody (ABIN6566722) Western blot analysis of extracts of various cell lines, using MSH6 antibody.
Image no. 2 for anti-MutS Homolog 6 (E. Coli) (MSH6) antibody (ABIN6566722) Immunohistochemistry of paraffin-embedded human colon using MSH6 antibody.
Image no. 3 for anti-MutS Homolog 6 (E. Coli) (MSH6) antibody (ABIN6566722) Immunohistochemistry of paraffin-embedded human amygdalitis using MSH6 antibody.
Image no. 4 for anti-MutS Homolog 6 (E. Coli) (MSH6) antibody (ABIN6566722) Immunofluorescence analysis of A549 cells using MSH6 antibody.